Issue 21, 2011

Ultra-sensitive microfibre absorption detection in a microfluidic chip

Abstract

We report a microfibre absorption sensor by using a 900 nm diameter silica microfibre embedded in a 125 μm wide microchannel with a detection length of 2.5 cm. Investigated by measuring the absorbance of methylene blue (MB), the sensor shows a detection limit down to 50 pM with excellent reversibility in a concentration range of 0–5 nM. The sensor has also been applied to bovine serum albumin (BSA) measurement, with a detection limit of 10 fg mL−1. In addition, the sample volume requirement is merely 500 nL with a probing light power of about 150 nW, which is very promising for safe detection of single or a few molecules of biological specimens.

Graphical abstract: Ultra-sensitive microfibre absorption detection in a microfluidic chip

Supplementary files

Article information

Article type
Technical Note
Submitted
14 Jun 2011
Accepted
25 Aug 2011
First published
23 Sep 2011

Lab Chip, 2011,11, 3720-3724

Ultra-sensitive microfibre absorption detection in a microfluidic chip

L. Zhang, P. Wang, Y. Xiao, H. Yu and L. Tong, Lab Chip, 2011, 11, 3720 DOI: 10.1039/C1LC20519F

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