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Issue 15, 2011
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DNA manipulation with elastomeric nanostructures fabricated by soft-moulding of a FIB-patterned stamp

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Abstract

A Focused Ion Beam (FIB)-patterned silicon mould is used to fabricate elastomeric nanostructures, whose cross-section can be dynamically and reversibly tuned by applying a controlled mechanical stress. Direct-write, based on FIB milling, allows the fabrication of nanostructures with a variety of different geometries, aspect ratio, spacing and distribution offering a higher flexibility compared to other nanopatterning approaches. Moreover, a simple double replication process based on poly(dimethylsiloxane) permits a strong reduction of the fabrication costs that makes this approach well-suited for the production of low cost nanofluidic devices. DNA stretching and single molecule manipulation capabilities of these platforms have been successfully demonstrated.

Graphical abstract: DNA manipulation with elastomeric nanostructures fabricated by soft-moulding of a FIB-patterned stamp

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Supplementary files

Article information


Submitted
13 May 2011
Accepted
23 May 2011
First published
15 Jun 2011

Lab Chip, 2011,11, 2625-2629
Article type
Technical Note

DNA manipulation with elastomeric nanostructures fabricated by soft-moulding of a FIB-patterned stamp

E. Angeli, C. Manneschi, L. Repetto, G. Firpo and U. Valbusa, Lab Chip, 2011, 11, 2625
DOI: 10.1039/C1LC20411D

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