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Issue 7, 2011
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Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup

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Abstract

The continuous flow focussing and manipulation of particles and cells are important factors in microfluidic applications for performing accurate and reproducible procedures downstream. Many particle focussing methods require complex setups or channel designs that can limit the process and its applications. Here, we present diamagnetic repulsion as a simple means of focussing objects in continuous flow, based only on their intrinsic properties without the requirement of any label. Diamagnetic polystyrene particles were suspended in a paramagnetic medium and pumped through a capillary between a pair of permanent magnets, whereupon the particles were repelled by each magnet into the central axis of the capillary, thus achieving focussing. By investigating this effect, we found that the focussing was greatly enhanced with (i) increased magnetic susceptibility of the medium, (ii) reduced flow rate of the suspension, (iii) increased particle size, and (iv) increased residence time in the magnetic field. Furthermore, we applied diamagnetic repulsion to the flow focussing of living, label-free HaCaT cells.

Graphical abstract: Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup

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Article information


Submitted
01 Oct 2010
Accepted
01 Dec 2010
First published
24 Dec 2010

Lab Chip, 2011,11, 1240-1248
Article type
Paper

Flow focussing of particles and cells based on their intrinsic properties using a simple diamagnetic repulsion setup

A. I. Rodríguez-Villarreal, M. D. Tarn, L. A. Madden, J. B. Lutz, J. Greenman, J. Samitier and N. Pamme, Lab Chip, 2011, 11, 1240
DOI: 10.1039/C0LC00464B

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