Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 5, 2011
Previous Article Next Article

Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)

Author affiliations

Abstract

We present a self-powered integrated microfluidic blood analysis system (SIMBAS) that does not require any external connections, tethers, or tubing to deliver and analyze a raw whole-blood sample. SIMBAS only requires the user to place a 5 μL droplet of whole-blood at the inlet port of the device, whereupon the stand-alone SIMBAS performs on-chip removal of red and white cells, without external valving or pumping mechanisms, followed by analyte detection in platelet-containing plasma. Five complete biotin–streptavidin sample-to-answer assays are performed in 10 min; the limit of detection is 1.5 pM. Red and white blood cells are removed by trapping them in an integral trench structure. Simulations and experimental data show 99.9% to 100% blood cell retention in the passive structure. Powered by pre-evacuation of its PDMS substrate, SIMBAS' guiding design principle is the integration of the minimal number of components without sacrificing effectiveness in performing rapid complete bioassays, a critical step towards point-of-care molecular diagnostics.

Graphical abstract: Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)

Back to tab navigation

Supplementary files

Additions and corrections

Article information


Submitted
12 Sep 2010
Accepted
19 Oct 2010
First published
08 Dec 2010

Lab Chip, 2011,11, 845-850
Article type
Paper

Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS)

I. K. Dimov, L. Basabe-Desmonts, J. L. Garcia-Cordero, B. M. Ross, A. J. Ricco and L. P. Lee, Lab Chip, 2011, 11, 845
DOI: 10.1039/C0LC00403K

Social activity

Search articles by author

Spotlight

Advertisements