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Issue 3, 2011
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Microfluidics analysis of red blood cell membrane viscoelasticity

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Abstract

In this work, a microfluidic system to investigate the flow behavior of red blood cells in a microcirculation-mimicking network of PDMS microchannels with thickness comparable to cell size is presented. We provide the first quantitative description of cell velocity and shape as a function of the applied pressure drop in such devices. Based on these results, a novel methodology to measure cell membrane viscoelastic properties in converging/diverging flow is developed, and the results are in good agreement with data from the literature. In particular, in the diverging channel the effect of RBC surface viscosity is dominant with respect to shear elasticity. Possible applications include measurements of cell deformability in pathological samples, where reliable methods are still lacking.

Graphical abstract: Microfluidics analysis of red blood cell membrane viscoelasticity

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Article information


Submitted
27 Aug 2010
Accepted
19 Oct 2010
First published
15 Nov 2010

Lab Chip, 2011,11, 449-454
Article type
Paper

Microfluidics analysis of red blood cell membrane viscoelasticity

G. Tomaiuolo, M. Barra, V. Preziosi, A. Cassinese, B. Rotoli and S. Guido, Lab Chip, 2011, 11, 449
DOI: 10.1039/C0LC00348D

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