Jump to main content
Jump to site search

Issue 34, 2011
Previous Article Next Article

Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer

Author affiliations

Abstract

Amine and carboxylic acid-bifunctionalized iron oxide nanoparticles with robust silane linkages to the nanoparticle surface were prepared with a versatile direct grafting protocol. The contrast in chemistry of these two groups was highlighted by attaching a fluorophore, Rhodamine B isothiocyanate (RITC) onto the amine group and an antibody (EPCAM – epithelial cell adhesion molecule) onto the carboxylic acid groups. The iron oxide core and the RITC tags provide the MRI-fluorescent bi-modal imaging capability. The EPCAM antibody is specific to a protein ubiquitously expressed on the epithelial cell surface. These bifunctionalized nanoparticles target and then undergo facilitated uptake into pancreatic cancer cells (Panc-1) in a time course-monitored controlled study. The integrated optical imaging properties of these magnetic nanoparticles were utilized to monitor the interaction of the nanoparticles with the EPCAM receptors on the cell membrane of the Panc-1 cells. The time-course of the uptake for the targeted and the control particles by the cells was followed allowing the localization within the cell and the impact of particle functionalization to be identified. This system is a candidate for further development as a multi-modular imaging, diagnostic and delivery tool.

Graphical abstract: Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Apr 2011, accepted on 15 Jun 2011 and first published on 22 Jul 2011


Article type: Paper
DOI: 10.1039/C1JM11370D
J. Mater. Chem., 2011,21, 12650-12659

  •   Request permissions

    Multifunctional Fe3O4 nanoparticles for targeted bi-modal imaging of pancreatic cancer

    C. I. Olariu, H. H. P. Yiu, L. Bouffier, T. Nedjadi, E. Costello, S. R. Williams, C. M. Halloran and M. J. Rosseinsky, J. Mater. Chem., 2011, 21, 12650
    DOI: 10.1039/C1JM11370D

Search articles by author

Spotlight

Advertisements