Issue 8, 2011
From the journal:

Journal of Materials Chemistry

Thermo-responsive protein adsorbing materials for purifying pharmaceuticalprotein on exposed charging surface†

Kenichi Nagase,a   Simuck F. Yuk,a   Jun Kobayashi,a   Akihiko Kikuchi,b   Yoshikatsu Akiyama,a   Hideko Kanazawac  and  Teruo Okano*a  

* Corresponding authors

a Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku, Tokyo, Japan
E-mail: tokano@abmes.twmu.ac.jp
Fax: +81 3 3359 6046
Tel: +81 3 5367 9945 ext. 6201

b Department of Materials Science and Technology, Tokyo University of Science, Chiba, Japan

c Faculty of Pharmacy, Keio University, Tokyo, Japan

Abstract

Thermo-responsive anionic terpolymer brushes with high selectivity for proteins were prepared though surface-initiated ATRP. Utilizing these terpolymer brushes, pure lysozyme was successfully separated from egg-white. Thus, the prepared thermo-responsive terpolymer brush is an effective separation tool for the pharmaceutical and biotechnological industries that produce valuable proteins.

Graphical abstract: Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

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Article information

DOI
https://doi.org/10.1039/C0JM03453C
Article type
Paper
Submitted
13 Oct 2010
Accepted
18 Nov 2010
First published
24 Dec 2010

J. Mater. Chem., 2011,21, 2590-2593

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Thermo-responsive protein adsorbing materials for purifying pharmaceutical protein on exposed charging surface

K. Nagase, S. F. Yuk, J. Kobayashi, A. Kikuchi, Y. Akiyama, H. Kanazawa and T. Okano, J. Mater. Chem., 2011, 21, 2590 DOI: 10.1039/C0JM03453C

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