Jump to main content
Jump to site search

Issue 8, 2011
Previous Article Next Article

A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction

Author affiliations

Abstract

A grinding-induced catalyst- and solvent-free domino multicomponent reaction for the synthesis of 1,4-dihydropyridines has been developed using aldehydes, amines, DEAD (diethyl acetylenedicarboxylate), and malononitrile/ethyl cyanoacetate. The synthesized 1,4-dihydropyridines were efficiently converted into novel tacrine analogs 7a–7e using micelle-promoted microwave irradiation.

Graphical abstract: A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction

Back to tab navigation

Supplementary files

Article information


Submitted
02 Mar 2011
Accepted
24 Mar 2011
First published
16 Jun 2011

Green Chem., 2011,13, 2017-2020
Article type
Communication

A grinding-induced catalyst- and solvent-free synthesis of highly functionalized 1,4-dihydropyridines via a domino multicomponent reaction

A. Kumar and S. Sharma, Green Chem., 2011, 13, 2017
DOI: 10.1039/C1GC15223H

Social activity

Search articles by author

Spotlight

Advertisements