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Issue 3, 2011
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“On water”-promoted direct alkynylation of isatins catalyzed by NHC–silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones

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Abstract

The direct alkynylation of isatins catalyzed by NHC–Ag complexes via the activation of alkyne C–H bond on water was developed for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones under an air atmosphere. A remarkable rate-enhancement by water in the aqueous heterogeneous system was observed.

Graphical abstract: “On water”-promoted direct alkynylation of isatins catalyzed by NHC–silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones

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Publication details

The article was received on 12 Nov 2010, accepted on 21 Dec 2010 and first published on 02 Feb 2011


Article type: Communication
DOI: 10.1039/C0GC00807A
Citation: Green Chem., 2011,13, 549-553

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    “On water”-promoted direct alkynylation of isatins catalyzed by NHC–silver complexes for the efficient synthesis of 3-hydroxy-3-ethynylindolin-2-ones

    X. Fu, L. Liu, D. Wang, Y. Chen and C. Li, Green Chem., 2011, 13, 549
    DOI: 10.1039/C0GC00807A

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