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Issue 8, 2011
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Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis

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Abstract

A novel BLAP (alkaline protease from Bacillus licheniformis) catalyzed synthesis of 2H-1-benzopyran-2-one derivatives was achieved by domino Knoevenagel/intramolecular transesterification reaction. The control of enzymatic chemoselectivity between Knoevenagel/intramolecular transesterification and Knoevenagel/intramolecular hemiketalization could be realized by adjusting parameters including solvent, water content and temperature. The products were obtained in acceptable yields. This BLAP catalyzed selective domino reaction provided an alternative synthetic method for 2H-1-benzopyran-2-one derivatives.

Graphical abstract: Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis

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Publication details

The article was received on 11 Nov 2010, accepted on 03 May 2011 and first published on 15 Jun 2011


Article type: Paper
DOI: 10.1039/C0GC00799D
Green Chem., 2011,13, 2048-2054

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    Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis

    C. Wang, Z. Guan and Y. He, Green Chem., 2011, 13, 2048
    DOI: 10.1039/C0GC00799D

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