Issue 4, 2011
From the journal:

Green Chemistry

Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes†

Shan Ding,a   Minhgiao Le-Nguyen,a   Tao Xua  and  Wei Zhang*a  

* Corresponding authors

a Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA, USA
E-mail: wei2.zhang@umb.edu

Abstract

Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes is accomplished by a three-step synthesis including multicomponent reaction (MCR) to form tetrahydroquinoline, followed by cycloaddition with coumarin to form oxazabicycles, and then a Suzuki coupling to introduce the biaryl group. Microwave irradiation and fluorous solid-phase extraction (F-SPE) are employed to speed up reactions and simplify product purification.

Graphical abstract: Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C0GC00725K
Article type
Communication
Submitted
24 Oct 2010
Accepted
16 Feb 2011
First published
08 Mar 2011

Green Chem., 2011,13, 847-849

Permissions

Request permissions

Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes

S. Ding, M. Le-Nguyen, T. Xu and W. Zhang, Green Chem., 2011, 13, 847 DOI: 10.1039/C0GC00725K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements