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Issue 1, 2011
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Efficient preparation of β-d-glucosyl and β-d-mannosyl ureas and other N-glucosides in carbohydrate melts

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Abstract

Sugar melts or solvent-free systems have been used to react simple unprotected hexoses at the C-1 atom with urea and urea derivatives to sugar-ureides by acid catalysis and with short reaction times. In one step, β-D-glucosyl- and β-D-mannosyl urea 2a/b were obtained in high yields. D-Galactose 6, N-acetyl-D-glucosamine 7, L-rhamnose 8 and 2-deoxy-D-glucose 9 were converted likewise to glycosyl ureas. Additionally, urea-related nucleophiles were investigated as melt components. N,N′-Ethylene urea 15, N,N′-allylurea 16 and ethyl carbamate 18 were β-selectively converted with D-glucose in good yield, giving the corresponding N-glycosides. Under these conditions, however, the condensation product with N-octylurea 17 was not accessible.

Graphical abstract: Efficient preparation of β-d-glucosyl and β-d-mannosyl ureas and other N-glucosides in carbohydrate melts

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Article information


Submitted
20 Aug 2010
Accepted
17 Nov 2010
First published
06 Dec 2010

Green Chem., 2011,13, 156-161
Article type
Paper

Efficient preparation of β-D-glucosyl and β-D-mannosyl ureas and other N-glucosides in carbohydrate melts

C. Ruß, F. Ilgen, C. Reil, C. Luff, A. Haji Begli and B. König, Green Chem., 2011, 13, 156
DOI: 10.1039/C0GC00468E

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