Volume 149, 2011
From the journal:

Faraday Discussions

Multiphoton microscopy of transdermal quantum dot delivery using two photonpolymerization-fabricated polymer microneedles

Shaun D. Gittard,a   Philip R. Miller,a   Ryan D. Boehm,a   Aleksandr Ovsianikov,b   Boris N. Chichkov,b   Jeremy Heiser,cd   John Gordon,cd   Nancy A. Monteiro-Riviereae  and  Roger J. Narayan*a  

* Corresponding authors

a Joint Department of Biomedical Engineering, University of North Carolina State University, Campus Box 7115, Raleigh, NC, USA
E-mail: roger_narayan@ncsu.edu
Fax: +1 509 696 8481

b Department of Nanotechnology, Laser Zentrum Hannover, Hollerithalle 8, Hannover, Germany

c Ceramatec Inc., 2425 South 900 West, Salt Lake City, UT, USA

d MicroLin LLC & Technology Holding LLC, 350 West 800 North, Suite 250, Salt Lake City, UT, USA

e Center for Chemical Toxicology Research & Pharmacokinetics, North Carolina State University, Raleigh, NC, USA

Abstract

Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy.

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Article information

DOI
https://doi.org/10.1039/C005374K
Article type
Paper
Submitted
18 May 2010
Accepted
22 Jun 2010
First published
23 Sep 2010

Faraday Discuss., 2011,149, 171-185

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Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles

S. D. Gittard, P. R. Miller, R. D. Boehm, A. Ovsianikov, B. N. Chichkov, J. Heiser, J. Gordon, N. A. Monteiro-Riviere and R. J. Narayan, Faraday Discuss., 2011, 149, 171 DOI: 10.1039/C005374K

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