Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 5, 2011
Previous Article Next Article

Advanced REACH Tool (ART): Calibration of the mechanistic model

Author affiliations


The mechanistic model of the Advanced Reach Tool (ART) provides a relative ranking of exposure levels from different scenarios. The objectives of the calibration described in this paper are threefold: to study whether the mechanistic model scores are accurately ranked in relation to exposure measurements; to enable the mechanistic model to estimate actual exposure levels rather than relative scores; and to provide a method of quantifying model uncertainty. Stringent data quality guidelines were applied to the collated data. Linear mixed effects models were used to evaluate the association between relative ART model scores and measurements. A random scenario and company component of variance were introduced to reflect the model uncertainty. Stratified analyses were conducted for different forms of exposure (abrasive dust, dust, vapours and mists). In total more than 2000 good quality measurements were available for the calibration of the mechanistic model. The calibration showed that after calibration the mechanistic model of ART was able to estimate geometric mean (GM) exposure levels with 90% confidence for a given scenario to lie within a factor between two and six of the measured GM depending upon the form of exposure.

Graphical abstract: Advanced REACH Tool (ART): Calibration of the mechanistic model

Back to tab navigation

Article information

05 Jan 2011
09 Feb 2011
First published
14 Mar 2011

J. Environ. Monit., 2011,13, 1374-1382
Article type

Advanced REACH Tool (ART): Calibration of the mechanistic model

J. Schinkel, N. Warren, W. Fransman, M. van Tongeren, P. McDonnell, E. Voogd, J. W. Cherrie, M. Tischer, H. Kromhout and E. Tielemans, J. Environ. Monit., 2011, 13, 1374
DOI: 10.1039/C1EM00007A

Search articles by author