Issue 38, 2011
From the journal:

Dalton Transactions

Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery

Tingting Wang,ab   Xuli Zhang,a   Ying Pan,c   Xiumin Miao,a   Zhongmin Su,a   Chungang Wang*a  and  Xiaomeng Li*c  

* Corresponding authors

a School of Chemistry, Northeast Normal University, Changchun, P. R. China
E-mail: wangcg925@nenu.edu.cn

b School of Chemistry & Environmental Engineering, Changchun University of Science and Technology, Changchun, P. R. China

c The Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun, P. R. China
E-mail: lixm441@nenu.edu.cn

Abstract

A novel strategy was utilized to develop a stable probe based on thiolated poly(ethylene glycol) (SH-PEG) and polyacrylic acid (PAA) functionalized gold nanorods (GNRs), following the attachment of an anti-cancer drug, doxorubicin (DOX), to obtain PAA-PEG-GNRs@DOX assemblies. Importantly, the obtained probe as a novel drug-delivery and fluorescent imaging agent for simultaneous imaging of and drug delivery to prostate cancer cells has also been demonstrated. In addition to designing PAA-PEG-GNRs that passively target tumor cells for cancer-fighting drug therapy, GNRs are also regarded as hyperthermia agents for photokilling cancer cells, so that the tumor would be attacked on two fronts simultaneously.

Graphical abstract: Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery

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Article information

DOI
https://doi.org/10.1039/C1DT10565E
Article type
Paper
Submitted
03 Apr 2011
Accepted
08 Jul 2011
First published
30 Aug 2011

Dalton Trans., 2011,40, 9789-9794

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Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery

T. Wang, X. Zhang, Y. Pan, X. Miao, Z. Su, C. Wang and X. Li, Dalton Trans., 2011, 40, 9789 DOI: 10.1039/C1DT10565E

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