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Issue 23, 2011
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One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co

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Abstract

We describe the synthesis of the dip (di-picolyl-carboxylate) bifunctional chelator system, capable of fast coordination of Cu2+, 64Cu2+ and Co2+, as well as the [M(CO)3]+-core (M = 99mTc, Re); it displays a variety of binding modes—tridentate when protected, tetradentate when deprotected. Syntheses of both the benzyl-nitro derivative and the benzyl-amino derivatives are described. The latter was coupled to biotin to show the viability of the system for functionalization with biomolecules. Besides coordination chemistry with stable isotopes, we also present labelling data with 64Cu and 99mTc, as well as in vitro stability studies.

Graphical abstract: One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co

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Publication details

The article was received on 23 Oct 2010, accepted on 23 Dec 2010 and first published on 10 Feb 2011


Article type: Paper
DOI: 10.1039/C0DT01458C
Citation: Dalton Trans., 2011,40, 6253-6259
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    One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co

    E. Boros, Y. S. Lin, C. L. Ferreira, B. O. Patrick, U. O. Häfeli, M. J. Adam and C. Orvig, Dalton Trans., 2011, 40, 6253
    DOI: 10.1039/C0DT01458C

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