Jump to main content
Jump to site search

Issue 33, 2011
Previous Article Next Article

Nitrosyl iron complexes—synthesis, structure and biology

Author affiliations

Abstract

Nitrosyl complexes of iron are formed in living species in the presence of nitric oxide. They are considered a form in which NO can be stored and stabilized within a living cell. Upon entering a topic in bioinorganic chemistry the researcher faces a wide spectrum of issues concerning synthetic methods, the structure and chemical properties of the complex on the one hand, and its biological implications on the other. The aim of this review is to present the newest knowledge on nitrosyl iron complexes, summarizing the issues that are important for understanding the nature of nitrosyl iron complexes, their possible interactions, behavior in vitro and in vivo, handling of the preparations etc. in response to the growing interest in these compounds. Herein we focus mostly on the dinitrosyl iron complexes (DNICs) due to their prevailing occurrence in NO-treated biological samples. This article reviews recent knowledge on the structure, chemical properties and biological action of DNICs and some mononitrosyls of heme proteins. Synthetic methods are also briefly reviewed.

Graphical abstract: Nitrosyl iron complexes—synthesis, structure and biology

Back to tab navigation

Publication details

The article was received on 16 Sep 2010, accepted on 13 Apr 2011 and first published on 06 Jun 2011


Article type: Perspective
DOI: 10.1039/C0DT01244K
Dalton Trans., 2011,40, 8273-8289

  •   Request permissions

    Nitrosyl iron complexes—synthesis, structure and biology

    H. Lewandowska, M. Kalinowska, K. Brzóska, K. Wójciuk, G. Wójciuk and M. Kruszewski, Dalton Trans., 2011, 40, 8273
    DOI: 10.1039/C0DT01244K

Search articles by author

Spotlight

Advertisements