Recent advances in asymmetric catalysis with cinchona alkaloid-based primary amines

Abstract

Six years have passed since renewed attention was paid to primary amines as potential organocatalysts in 2004. Numerous high quality studies in this field have provided chemists with valuable insights into the unique properties of chiral primary aminocatalysis. Among the diverse catalysts, natural cinchona alkaloid-derived catalysts have been widely regarded as a branch with high efficiency. This review examines the literature published between 2008 and late 2010, concerning cinchona alkaloid-derived primary amine catalysis.