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Issue 11, 2011
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The MXCXXC class of metallochaperone proteins: model studies

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Abstract

Transition metal ions can be both beneficial and harmful to biological systems if not carefully regulated. A family of proteins that include a conserved sequence in their binding site of MXCXXC is responsible for delivery and homeostasis of different metals. Model studies present an effective tool for studying the parameters governing metal affinity, selectivity and other mechanistic aspects. Small-molecule, peptide-based, and advanced models will be presented, as well as functional models of potential industrial applications.

Graphical abstract: The MXCXXC class of metallochaperone proteins: model studies

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Article information


Submitted
31 Mar 2011
First published
22 Jun 2011

Chem. Soc. Rev., 2011,40, 5282-5292
Article type
Tutorial Review

The MXCXXC class of metallochaperone proteins: model studies

M. S. Shoshan and E. Y. Tshuva, Chem. Soc. Rev., 2011, 40, 5282
DOI: 10.1039/C1CS15086C

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