Jump to main content
Jump to site search

Issue 9, 2011
Previous Article Next Article

Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals

Author affiliations

Abstract

In recent years, numerous in vivo molecular imaging probes have been developed. As a consequence, much has been published on the design and synthesis of molecular imaging probes focusing on each modality, each type of material, or each target disease. More recently, second generation molecular imaging probes with unique, multi-functional, or multiplexed characteristics have been designed. This critical review focuses on (i) molecular imaging using combinations of modalities and signals that employ the full range of the electromagnetic spectra, (ii) optimized chemical design of molecular imaging probes for in vivo kinetics based on biology and physiology across a range of physical sizes, (iii) practical examples of second generation molecular imaging probes designed to extract complementary data from targets using multiple modalities, color, and comprehensive signals (277 references).

Graphical abstract: Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals

Back to tab navigation

Publication details

The article was received on 25 Mar 2011 and first published on 23 May 2011


Article type: Critical Review
DOI: 10.1039/C1CS15077D
Citation: Chem. Soc. Rev., 2011,40, 4626-4648

  •   Request permissions

    Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals

    H. Kobayashi, M. R. Longmire, M. Ogawa and P. L. Choyke, Chem. Soc. Rev., 2011, 40, 4626
    DOI: 10.1039/C1CS15077D

Search articles by author

Spotlight

Advertisements