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Issue 10, 2011
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Cross-coupling in flow

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Until recently, cross-coupling reactions have been exclusively performed in batch processes. With the advent of microfluidics, significant effort has been devoted to develop a wide variety of continuous-flow techniques to facilitate organic synthesis. In this critical review, we attempt to give an overview of the different continuous-flow methodologies that have been developed and utilized for cross-coupling reactions. In addition, we attempt to point out the advantages of continuous-flow when compared with their batch counterparts (246 references).

Graphical abstract: Cross-coupling in flow

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Article information

22 Mar 2011
First published
08 Aug 2011

Chem. Soc. Rev., 2011,40, 5010-5029
Article type
Critical Review

Cross-coupling in flow

T. Noël and S. L. Buchwald, Chem. Soc. Rev., 2011, 40, 5010
DOI: 10.1039/C1CS15075H

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