Issue 7, 2011
From the journal:

Chemical Society Reviews

Tailoring nanocarriers for intracellular protein delivery

Zhen Gu,†‡*abc   Anuradha Biswas,†ab   Muxun Zhaoab  and  Yi Tang*abd  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of California at Los Angeles, Los Angeles (UCLA), California 90095, USA

b California NanoSystems Institute, University of California at Los Angeles, Los Angeles (UCLA), California 90095, USA

c Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles (UCLA), California 90095, USA
E-mail: guzhen@mit.edu; yitang@ucla.edu

d Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles (UCLA), California 90095, USA

Abstract

Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering active forms of proteins to specific cells and organs. Intracellular protein delivery holds enormous promise for biological and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic diseases and imaging. This tutorial review surveys recent developments in intracellular protein delivery using various nanocarriers. Methods such as lipid-mediated colloidal systems, polymeric nanocarriers, inorganic systems and protein-mediated carriers are reviewed. Advantages and limitations of current strategies, as well as future opportunities and challenges are also discussed.

Graphical abstract: Tailoring nanocarriers for intracellular protein delivery

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Article information

DOI
https://doi.org/10.1039/C0CS00227E
Article type
Tutorial Review
Submitted
31 Dec 2010
First published
12 May 2011

Chem. Soc. Rev., 2011,40, 3638-3655

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Tailoring nanocarriers for intracellular protein delivery

Z. Gu, A. Biswas, M. Zhao and Y. Tang, Chem. Soc. Rev., 2011, 40, 3638 DOI: 10.1039/C0CS00227E

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