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Issue 5, 2011
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Ball milling in organic synthesis: solutions and challenges

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During the last decade numerous protocols have been published using the method of ball milling for synthesis all over the field of organic chemistry. However, compared to other methods leaving their marks on the road to sustainable synthesis (e.g. microwave, ultrasound, ionic liquids) chemistry in ball mills is rather underrepresented in the knowledge of organic chemists. Especially, in the last three years the interest in this technique raised continuously, culminating in several high-quality synthetic procedures covering the whole range of organic synthesis. Thus, the present tutorial review will be focused on the highlights using this method of energy transfer and energy dissipation. The central aim is to motivate researchers to take notice of ball mills as chemical reactors, implementing this technique in everyday laboratory use and thus, pave the ground for future activities in this interdisciplinary field of research.

Graphical abstract: Ball milling in organic synthesis: solutions and challenges

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The article was received on 29 Nov 2010, accepted on 10 Feb 2011 and first published on 08 Mar 2011

Article type: Tutorial Review
DOI: 10.1039/C0CS00195C
Chem. Soc. Rev., 2011,40, 2317-2329

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    Ball milling in organic synthesis: solutions and challenges

    A. Stolle, T. Szuppa, S. E. S. Leonhardt and B. Ondruschka, Chem. Soc. Rev., 2011, 40, 2317
    DOI: 10.1039/C0CS00195C

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