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Issue 4, 2011
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Role of metal–oxo complexes in the cleavage of C–H bonds

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Abstract

The functionalization of C–H bonds has yet to achieve widespread use in synthetic chemistry in part because of the lack of synthetic reagents that function in the presence of other functional groups. These problems have been overcome in enzymes, which have metal–oxo active sites that efficiently and selectively cleave C–H bonds. How high-energy metal–oxo transient species can perform such difficult transformations with high fidelity is discussed in this tutorial review. Highlighted are the relationships between redox potentials and metal–oxo basicity on C–H bond activation, as seen in a series of bioinspired manganese–oxo complexes.

Graphical abstract: Role of metal–oxo complexes in the cleavage of C–H bonds

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Publication details

The article was received on 03 Nov 2010 and first published on 01 Mar 2011


Article type: Tutorial Review
DOI: 10.1039/C0CS00165A
Citation: Chem. Soc. Rev., 2011,40, 1870-1874

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    Role of metal–oxo complexes in the cleavage of C–H bonds

    A. S. Borovik, Chem. Soc. Rev., 2011, 40, 1870
    DOI: 10.1039/C0CS00165A

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