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Issue 8, 2011
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De novo designed peptides for biological applications

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Abstract

In recent years our ability to design and assemble peptide-based materials and objects de novo (i.e. from first principles) has improved considerably. This brings us to a point where the resulting assemblies are quite sophisticated and amenable to engineering in new functions. Whilst such systems could be used in a variety of ways, biological applications are of particular interest because of the demand for biocompatible, readily produced systems with potential as drug-delivery agents, components of biosensors and scaffolds for 3D cell and tissue culture. This tutorial review describes the building blocks (or tectons) that are being used in peptide assembly, highlights a range of materials and objects that have been produced, notably hydrogels and virus-like particles, and introduces a number of potential applications for the designs.

Graphical abstract: De novo designed peptides for biological applications

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Article information


Submitted
20 Oct 2010
First published
04 Mar 2011

Chem. Soc. Rev., 2011,40, 4295-4306
Article type
Tutorial Review

De novo designed peptides for biological applications

A. L. Boyle and D. N. Woolfson, Chem. Soc. Rev., 2011, 40, 4295
DOI: 10.1039/C0CS00152J

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