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Issue 33, 2011
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Enhancement of hematoporphyrin IX potential for photodynamic therapy by entrapment in silica nanospheres

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Abstract

The entrapment of hematoporphyrin IX (Hp IX) in silica by means of a microemulsion resulted in silica spheres of 33 ± 6 nm. The small size, narrow size distribution and lack of aggregation maintain Hp IX silica nanospheres stable in aqueous solutions for long periods and permit a detailed study of the entrapped drug by different techniques. Hp IX entrapped in the silica matrix is accessed by oxygen and upon irradiation generates singlet oxygen which diffuses very efficiently to the outside solution. The Hp IX entrapped in the silica matrix is also reached by iron(II) ions, which causes quenching of the porphyrin fluorescence emission. The silica matrix also provides extra protection to the photosensitizer against interaction with BSA and ascorbic acid, which are known to cause suppression of singlet oxygen generation by the Hp IX free in solution. Therefore, the incorporation of Hp IX molecules into silica nanospheres increased the potential of the photosensitizer to perform photodynamic therapy.

Graphical abstract: Enhancement of hematoporphyrin IX potential for photodynamic therapy by entrapment in silica nanospheres

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Article information


Submitted
12 May 2011
Accepted
17 Jun 2011
First published
19 Jul 2011

Phys. Chem. Chem. Phys., 2011,13, 14946-14952
Article type
Paper

Enhancement of hematoporphyrin IX potential for photodynamic therapy by entrapment in silica nanospheres

P. R. Silva, L. L. R. Vono, B. P. Espósito, M. S. Baptista and L. M. Rossi, Phys. Chem. Chem. Phys., 2011, 13, 14946
DOI: 10.1039/C1CP21525F

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