Jump to main content
Jump to site search

Issue 32, 2011
Previous Article Next Article

π-Stacking between Casiopeinas® and DNA bases

Author affiliations

Abstract

Casiopeínas® are copper complexes with the general formula [Cu(N–N)(N–O)]NO3 and [Cu(N–N)(O–O)]NO3 where N–N denotes a substituted bipyridine or phenanthroline, N–O indicates α-aminoacidate or peptide and O–O represents acetylacetonate or salicylaldehyde. This family of compounds has been evaluated in vitro and in vivo showing cytotoxic, genotoxic, and antineoplastic activity. The action mechanism is still not completely elucidated, but the possibility exists that these compounds interact with DNA by intercalation due to the aromatic moiety. In this work we found, using the properties of the electron density of a π-complex model base–Casiopeína®–base, that the stacking mechanism between Casiopeínas® and DNA bases is due to an electron density deficiency of the ligand of the Casiopeína® which is compensated for by an electron transfer from adenines by a π–π interaction.

Graphical abstract: π-Stacking between Casiopeinas® and DNA bases

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Jan 2011, accepted on 19 May 2011 and first published on 12 Jul 2011


Article type: Paper
DOI: 10.1039/C1CP20183B
Citation: Phys. Chem. Chem. Phys., 2011,13, 14510-14515
  •   Request permissions

    π-Stacking between Casiopeinas® and DNA bases

    R. Galindo-Murillo, J. Hernandez-Lima, M. González-Rendón, F. Cortés-Guzmán, L. Ruíz-Azuara and R. Moreno-Esparza, Phys. Chem. Chem. Phys., 2011, 13, 14510
    DOI: 10.1039/C1CP20183B

Search articles by author

Spotlight

Advertisements