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Issue 22, 2011
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Multiscale modeling of biological functions

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Recent years have witnessed a tremendous explosion in computational power, which in turn has resulted in great progress in the complexity of the biological and chemical problems that can be addressed by means of all-atom simulations. Despite this, however, our computational time is not infinite, and in fact many of the key problems of the field were resolved long before the existence of the current levels of computational power. This review will start by presenting a brief historical overview of the use of multiscale simulations in biology, and then present some key developments in the field, highlighting several cases where the use of a physically sound simplification is clearly superior to a brute-force approach. Finally, some potential future directions will be discussed.

Graphical abstract: Multiscale modeling of biological functions

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Article information

08 Dec 2010
23 Feb 2011
First published
27 Apr 2011

Phys. Chem. Chem. Phys., 2011,13, 10401-10411
Article type

Multiscale modeling of biological functions

S. C. L. Kamerlin and A. Warshel, Phys. Chem. Chem. Phys., 2011, 13, 10401
DOI: 10.1039/C0CP02823A

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