Jump to main content
Jump to site search

Issue 21, 2011
Previous Article Next Article

A multimodal magnetic resonance imaging nanoplatform for cancer theranostics

Author affiliations


We describe an innovative multimodal system, which combines magnetic targeting of therapeutic agents with both magnetic resonance and fluorescence imaging into one system. This new magnetic nanoplatform consists of superparamagnetic γFe2O3 nanoparticles, used clinically as an MRI contrast agent, conjugated to therapeutic molecules of the hydroxylmethylene bisphosphonate family (HMBPs): alendronate with an amine function as the terminal group. In vitro tests with breast cancer cells show that the γFe2O3@alendronate hybrid nanomaterial reduces cell viability and acts as a drug delivery system. We also investigated the anti-tumoural properties in vivo in nude mice xenografted with MDA-MB-231 tumours. We show that the presence of both γFe2O3@alendronate and a magnetic field significantly reduced the development of tumours. The amine functionalities can be used as precursor groups for the covalent coupling of peptides or monoclonal antibodies for specific biological targeting. The feasibility of this process was demonstrated by coupling rhodamine B, a fluorescence marker, to the γFe2O3@alendronate nanohybrid. The system showed fluorescent properties and high affinity for cells. Flow cytometry and fluorescence microscopy were used to study the kinetics of γFe2O3@alendronate uptake by cells. The magnetic and fluorescent nanoparticles are potential candidates for smart drug-delivery systems. Also, the superparamagnetic behaviour of such nanoparticles may be exploited as MRI contrast agents to improve therapeutic diagnostics.

Graphical abstract: A multimodal magnetic resonance imaging nanoplatform for cancer theranostics

Back to tab navigation

Supplementary files

Article information

04 Oct 2010
04 Feb 2011
First published
15 Mar 2011

Phys. Chem. Chem. Phys., 2011,13, 10020-10027
Article type

A multimodal magnetic resonance imaging nanoplatform for cancer theranostics

F. Benyettou, Y. Lalatonne, I. Chebbi, M. D. Benedetto, J. Serfaty, M. Lecouvey and L. Motte, Phys. Chem. Chem. Phys., 2011, 13, 10020
DOI: 10.1039/C0CP02034F

Social activity

Search articles by author