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Issue 12, 2012
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Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy

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Abstract

Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin.

Graphical abstract: Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy

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Supplementary files

Article information


Submitted
06 Oct 2011
Accepted
12 Dec 2011
First published
13 Dec 2011

Chem. Commun., 2012,48, 1754-1756
Article type
Communication

Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy

A. Díaz, V. Saxena, J. González, A. David, B. Casañas, C. Carpenter, J. D. Batteas, J. L. Colón, A. Clearfield and M. Delwar Hussain, Chem. Commun., 2012, 48, 1754
DOI: 10.1039/C2CC16218K

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