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Issue 46, 2011
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Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

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Abstract

A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.

Graphical abstract: Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

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Publication details

The article was received on 15 Sep 2011, accepted on 12 Oct 2011 and first published on 24 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC15716G
Chem. Commun., 2011,47, 12547-12549

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    Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

    E. Bertrand, C. Gonçalves, L. Billiet, J. P. Gomez, C. Pichon, H. Cheradame, P. Midoux and P. Guégan, Chem. Commun., 2011, 47, 12547
    DOI: 10.1039/C1CC15716G

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