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Issue 47, 2011
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Continuous in situ generation and reaction of phosgene in a microflow system

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Abstract

Continuous in situ generation of phosgene and its use in acid chloride formation in a microflow system were demonstrated. The acid chloride was subsequently coupled with an amine in high yield without severe epimerization.

Graphical abstract: Continuous in situ generation and reaction of phosgene in a microflow system

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Article information


Submitted
13 Sep 2011
Accepted
14 Oct 2011
First published
31 Oct 2011

Chem. Commun., 2011,47, 12661-12663
Article type
Communication

Continuous in situ generation and reaction of phosgene in a microflow system

S. Fuse, N. Tanabe and T. Takahashi, Chem. Commun., 2011, 47, 12661
DOI: 10.1039/C1CC15662D

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