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Issue 44, 2011
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Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures

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Abstract

A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37–42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent.

Graphical abstract: Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures

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Article information


Submitted
28 Aug 2011
Accepted
23 Sep 2011
First published
12 Oct 2011

Chem. Commun., 2011,47, 12146-12148
Article type
Communication

Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures

A. Castonguay, E. Wilson, N. Al-Hajaj, L. Petitjean, J. Paoletti, D. Maysinger and A. Kakkar, Chem. Commun., 2011, 47, 12146
DOI: 10.1039/C1CC15354D

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