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Issue 44, 2011
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An artificial metalloenzyme for olefin metathesis

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A Grubbs–Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.

Graphical abstract: An artificial metalloenzyme for olefin metathesis

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Supplementary files

Article information

11 Aug 2011
26 Sep 2011
First published
12 Oct 2011

Chem. Commun., 2011,47, 12068-12070
Article type

An artificial metalloenzyme for olefin metathesis

C. Mayer, D. G. Gillingham, T. R. Ward and D. Hilvert, Chem. Commun., 2011, 47, 12068
DOI: 10.1039/C1CC15005G

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