Jump to main content
Jump to site search

Issue 36, 2011
Previous Article Next Article

Catalytic enantioselective Grignard Nozaki–Hiyama methallylation from the alcohol oxidation level: chloride compensates for π-complex instability

Author affiliations

Abstract

Methallyl chloride serves as an efficient allyl donor in highly enantioselective Grignard Nozaki–Hiyama methallylations from the alcohol or aldehyde oxidation level viairidium catalyzed transfer hydrogenation. Under identical conditions, methallyl acetate does not react efficiently. Double methallylation of 1,3-propanediol provides the C2-symmetric adduct as a single enantiomer, as determined by HPLC analysis.

Graphical abstract: Catalytic enantioselective Grignard Nozaki–Hiyama methallylation from the alcohol oxidation level: chloride compensates for π-complex instability

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Jul 2011, accepted on 20 Jul 2011 and first published on 10 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC14392A
Chem. Commun., 2011,47, 10028-10030

  •   Request permissions

    Catalytic enantioselective Grignard Nozaki–Hiyama methallylation from the alcohol oxidation level: chloride compensates for π-complex instability

    A. Hassan, I. A. Townsend and M. J. Krische, Chem. Commun., 2011, 47, 10028
    DOI: 10.1039/C1CC14392A

Search articles by author

Spotlight

Advertisements