Issue 40, 2011

A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies

Abstract

A Zn2+ tetraazamacrocycle complex (2) bearing three naphthalene moieties has been prepared. Complex 2 recognizes, binds and causes damage to DNA, and shows considerable cytotoxicity against human cervical (HeLa), breast (MCF-7) and lung (NCI-H157) cancer cell lines with a different apoptotic pathway from that of cisplatin.

Graphical abstract: A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies

Supplementary files

Article information

Article type
Communication
Submitted
08 Jul 2011
Accepted
31 Aug 2011
First published
13 Sep 2011

Chem. Commun., 2011,47, 11330-11332

A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies

J. Wen, C. Li, Z. Geng, X. Ma and Z. Wang, Chem. Commun., 2011, 47, 11330 DOI: 10.1039/C1CC14107D

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