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Issue 38, 2011

Diastereo- and enantioselective conjugate addition of α-substituted nitroacetates to maleimides under base-free neutral phase-transfer conditions

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Abstract

Highly diastereo- and enantioselective conjugate addition of α-substituted nitroacetates to maleimides under base-free neutral phase-transfer conditions was developed for the synthesis of α,α-disubstituted α-amino acid derivatives.

Graphical abstract: Diastereo- and enantioselective conjugate addition of α-substituted nitroacetates to maleimides under base-free neutral phase-transfer conditions

Supplementary files

Article information


Submitted
06 Jul 2011
Accepted
09 Aug 2011
First published
25 Aug 2011

Chem. Commun., 2011,47, 10557-10559
Article type
Communication

Diastereo- and enantioselective conjugate addition of α-substituted nitroacetates to maleimides under base-free neutral phase-transfer conditions

S. Shirakawa, S. J. Terao, R. He and K. Maruoka, Chem. Commun., 2011, 47, 10557 DOI: 10.1039/C1CC14043D

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