Issue 38, 2011
From the journal:

Chemical Communications

Synthesis of the ABH rings of ecteinascidin 597 using a connective Pummerer-type cyclisation†

Laura H. S. Smith,a   Trung Thanh Nguyen,a   Helen F. Sneddonb  and  David J. Procter*a  

* Corresponding authors

a School of Chemistry, University of Manchester, Oxford Road, Manchester, UK
E-mail: david.j.procter@manchester.ac.uk

b Medicines Research Centre, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts, UK

Abstract

A connective Pummerer-type cyclisation involving a cysteine derivative and an N-benzyl glyoxamide 3 has been applied in an asymmetric synthesis of the protected ABH rings 2 of the antitumour and antimicrobial natural product ecteinascidin 597.

Graphical abstract: Synthesis of the ABH rings of ecteinascidin 597 using a connective Pummerer-type cyclisation

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Article information

DOI
https://doi.org/10.1039/C1CC13992D
Article type
Communication
Submitted
04 Jul 2011
Accepted
09 Aug 2011
First published
24 Aug 2011

Chem. Commun., 2011,47, 10821-10823

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Synthesis of the ABH rings of ecteinascidin 597 using a connective Pummerer-type cyclisation

L. H. S. Smith, T. T. Nguyen, H. F. Sneddon and D. J. Procter, Chem. Commun., 2011, 47, 10821 DOI: 10.1039/C1CC13992D

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