Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 38, 2011
Previous Article Next Article

A synthetic approach to kingianin A based on biosynthetic speculation

Author affiliations

Abstract

A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions, inspired through biosynthetic speculation. A concise protecting group free synthesis of the proposed monomeric precursor pre-kingianin A has been achieved using a tandem Stille cross-coupling reaction and electrocyclisation process. However, preliminary studies of the key dimerisation reaction have been conducted, which indicate that the process is not spontaneous, raising questions as to the origin of this complex natural product.

Graphical abstract: A synthetic approach to kingianin A based on biosynthetic speculation

Back to tab navigation

Supplementary files

Article information


Submitted
01 Jul 2011
Accepted
05 Aug 2011
First published
24 Aug 2011

Chem. Commun., 2011,47, 10605-10607
Article type
Communication

A synthetic approach to kingianin A based on biosynthetic speculation

P. Sharma, D. J. Ritson, J. Burnley and J. E. Moses, Chem. Commun., 2011, 47, 10605
DOI: 10.1039/C1CC13949E

Social activity

Search articles by author

Spotlight

Advertisements