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Issue 38, 2011
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Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

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Abstract

Glycosynthase mutants of Rhodococcus sp. endo-glycoceramidase II efficiently synthesize complex glycosphingolipids. Glycosyl fluoride donors may be assembled via sequential glycosyltransferase-catalysed glycosylation of lactosyl fluoride. Alternatively, lactosyl fluoride may be coupled to sphingosine prior to subsequent glycosylation steps.

Graphical abstract: Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

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Publication details

The article was received on 30 Jun 2011, accepted on 16 Aug 2011 and first published on 30 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13885E
Chem. Commun., 2011,47, 10806-10808

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    Glycosphingolipid synthesis employing a combination of recombinant glycosyltransferases and an endoglycoceramidase glycosynthase

    J. R. Rich, A. Cunningham, M. Gilbert and S. G. Withers, Chem. Commun., 2011, 47, 10806
    DOI: 10.1039/C1CC13885E

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