Issue 36, 2011

Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

Abstract

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

Graphical abstract: Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2011
Accepted
22 Jul 2011
First published
10 Aug 2011

Chem. Commun., 2011,47, 10025-10027

Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ

M. A. DeSieno, W. A. van der Donk and H. Zhao, Chem. Commun., 2011, 47, 10025 DOI: 10.1039/C1CC13597J

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