Issue 35, 2011
From the journal:

Chemical Communications

First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde†

Baptiste Lecachey,a   Catherine Fressigné,a   Hassan Oulyadi,a   Anne Harrison-Marchand*a  and  Jacques Maddaluno*a  

* Corresponding authors

a CNRS UMR 6014 & FR 3038, Université de Rouen and INSA de Rouen, 76821 Mont St Aignan Cedex, France
E-mail: anne.harrison@univ-rouen.fr, jmaddalu@crihan.fr
Fax: +33 235 522 971
Tel: +33 235 522 438

Abstract

A substoichiometric enantioselective version of the extremely fast nucleophilic addition of Alk-Li to RCHO is made possible thanks to a thorough analysis of the aggregation phenomena involved in the reaction: calculated quantities of LiCl must be added to the medium at the right time to keep the catalytic cycle running.

Graphical abstract: First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde

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Article information

DOI
https://doi.org/10.1039/C1CC13513A
Article type
Communication
Submitted
14 Jun 2011
Accepted
19 Jul 2011
First published
03 Aug 2011

Chem. Commun., 2011,47, 9915-9917

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First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde

B. Lecachey, C. Fressigné, H. Oulyadi, A. Harrison-Marchand and J. Maddaluno, Chem. Commun., 2011, 47, 9915 DOI: 10.1039/C1CC13513A

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