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Issue 39, 2011
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Light-controlled DNA binding of bisbenzamidines

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Abstract

Caging of the amidinium moieties of two representative bisbenzamidine DNA binders with suitable photoresponsive protecting groups suppresses their DNA-binding, which can then be fully recovered upon irradiation with UV light that removes the caging groups, regenerating the parent compounds. Moreover, a caged aza-pentamidine (©1a) is inert against Candida albicans, but displays a potent growth inhibitory activity after irradiation with UV light.

Graphical abstract: Light-controlled DNA binding of bisbenzamidines

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Article information


Submitted
06 Jun 2011
Accepted
16 Aug 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 11107-11109
Article type
Communication

Light-controlled DNA binding of bisbenzamidines

M. I. Sánchez, O. Vázquez, M. E. Vázquez and J. L. Mascareñas, Chem. Commun., 2011, 47, 11107
DOI: 10.1039/C1CC13355A

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