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Issue 32, 2011
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Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides

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Abstract

A chemoenzymatic method was developed for the synthesis of macrocyclic peptides and glycopeptides. Sortase A was found to mediate either head to tail cyclization or oligomerization and then head to tail cyclization of peptides and glycopeptides, depending on the peptide length, to produce 15-mer or higher cyclic peptides and glycopeptides.

Graphical abstract: Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides

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Publication details

The article was received on 04 Jun 2011, accepted on 20 Jun 2011 and first published on 08 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC13322E
Chem. Commun., 2011,47, 9218-9220

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    Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides

    Z. Wu, X. Guo and Z. Guo, Chem. Commun., 2011, 47, 9218
    DOI: 10.1039/C1CC13322E

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