Jump to main content
Jump to site search

Issue 33, 2011
Previous Article Next Article

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

Author affiliations

Abstract

We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.

Graphical abstract: Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 May 2011, accepted on 30 Jun 2011 and first published on 25 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC13213J
Chem. Commun., 2011,47, 9321-9323

  •   Request permissions

    Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

    M. Ciobanu, K. Huang, J. Daguer, S. Barluenga, O. Chaloin, E. Schaeffer, C. G. Mueller, D. A. Mitchell and N. Winssinger, Chem. Commun., 2011, 47, 9321
    DOI: 10.1039/C1CC13213J

Search articles by author

Spotlight

Advertisements