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Issue 34, 2011
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Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue

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Abstract

The glycan moiety of ganglioside HPG-7, isolated from the sea cucumber (Holothuria pervicax), was synthesized for the first time. The characteristic substructure, a trisialic acid sequence embedded in the glycan, was deliberately constructed by utilizing suitably differentiated sialyl units for various synthetic purposes. Finally, a pentasaccharide was successfully delivered as the hexyl glycoside.

Graphical abstract: Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue

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Publication details

The article was received on 31 May 2011, accepted on 11 Jul 2011 and first published on 21 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC13200H
Chem. Commun., 2011,47, 9726-9728

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    Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue

    Y. Iwayama, H. Ando, H. Tanaka, H. Ishida and M. Kiso, Chem. Commun., 2011, 47, 9726
    DOI: 10.1039/C1CC13200H

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