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Issue 31, 2011
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Automated solid phase synthesis of teichoic acids

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Abstract

This communication describes the first automated solid phase synthesis of teichoic acids (TAs) and the preparation by this method of a number of well-defined TA structures, which were probed for their antigenicity. An opsonophagocytic killing assay revealed a clear TA-length–activity relationship and indicated a promising candidate for future vaccine development.

Graphical abstract: Automated solid phase synthesis of teichoic acids

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Publication details

The article was received on 27 May 2011, accepted on 27 Jun 2011 and first published on 06 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC13132J
Chem. Commun., 2011,47, 8961-8963

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    Automated solid phase synthesis of teichoic acids

    W. F. J. Hogendorf, N. Meeuwenoord, H. S. Overkleeft, D. V. Filippov, D. Laverde, A. Kropec, J. Huebner, G. A. Van der Marel and J. D. C. Codée, Chem. Commun., 2011, 47, 8961
    DOI: 10.1039/C1CC13132J

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