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Issue 37, 2011
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cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

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Abstract

A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with Aβ peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.

Graphical abstract: cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

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Publication details

The article was received on 24 May 2011, accepted on 28 Jul 2011 and first published on 22 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13046C
Chem. Commun., 2011,47, 10266-10268

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    cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

    C. Airoldi, F. Cardona, E. Sironi, L. Colombo, M. Salmona, A. Silva, F. Nicotra and B. La Ferla, Chem. Commun., 2011, 47, 10266
    DOI: 10.1039/C1CC13046C

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