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Issue 33, 2011
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Targeted pH-dependent fluorescent activity-based cathepsin probes

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Abstract

Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition.

Graphical abstract: Targeted pH-dependent fluorescent activity-based cathepsin probes

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Publication details

The article was received on 19 May 2011, accepted on 29 Jun 2011 and first published on 18 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC12947C
Chem. Commun., 2011,47, 9363-9365

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    Targeted pH-dependent fluorescent activity-based cathepsin probes

    S. Hoogendoorn, K. L. Habets, S. Passemard, J. Kuiper, G. A. van der Marel, B. I. Florea and H. S. Overkleeft, Chem. Commun., 2011, 47, 9363
    DOI: 10.1039/C1CC12947C

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