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Issue 30, 2011
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Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

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Abstract

An N-terminal and C-terminal truncated recombinant α2–6-sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15–501)-His6, was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.

Graphical abstract: Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

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Publication details

The article was received on 10 May 2011, accepted on 15 Jun 2011 and first published on 01 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC12732B
Chem. Commun., 2011,47, 8691-8693

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    Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

    L. Ding, H. Yu, K. Lau, Y. Li, S. Muthana, J. Wang and X. Chen, Chem. Commun., 2011, 47, 8691
    DOI: 10.1039/C1CC12732B

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